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EC activation/injury by inflammatory stimuli, PAMPs and alarmins can generate signals mediating platelet accumulation and activation.
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GP IIb/IIIa is the central platelet receptor mediating platelet aggregation.
Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.
Our studies show the involvement of FcγRIIA in mediating platelet activation in the presence ACPA.
The process of and factors mediating platelet-platelet and platelet-leukocyte interactions in inflammatory and immune responses are discussed, with the roles of P-selectin, chemokines and Src family kinases being highlighted.
Morrell, C. N. et al. Glutamate mediates platelet activation through the AMPA receptor.
Godyna, S., Diaz-Ricart, M. & Argraves, W.S. Fibulin-1 mediates platelet adhesion via a bridge of fibrinogen.
Collagen interacts directly with platelets via glycoprotein VI (GpVI), which mediates platelet activation, and integrin α2β1, which supports platelet adhesion to collagen.
Addition of gelatin to the collagen composition reduced the degree of integrin mediated platelet binding.
10 Endothelial cells regulate thrombosis through the release of paracrine factors that mediate platelet function.
The αIIbβ3 integrin is abundantly expressed on the surface of platelets and mediates platelet aggregation and adhesion.
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