Sentence examples for mediating phosphorylation of from inspiring English sources

AMPK inhibits the activation of mTOR complex indirectly by mediating phosphorylation of the mTOR upstream regulator TSC2 to keep it suppressed [38] or directly via phosphorylation of the mTOR regulatory component, Raptor, to trigger its sequestration by 14-3-3 14-3-3 14-3-3t dissociandon from mTOR [39].

One such scaffold complex, containing presenilin, has previously been implicated in mediating phosphorylation of β-catenin [63].

To reinforce the physiological validity of the responses measured by ICW, we performed experiments in the presence or absence of pharmacologic inhibitors known to perturb the biochemical pathways mediating phosphorylation of MLC20.

Our previous studies have demonstrated a specific role for AC1 and AC8 in mediating phosphorylation of a discrete subset of PKA targets following acute ethanol treatment in the adult mouse brain [1].

Scansite 2.0 predicted Cdk1 and ERK1/2 as strong candidates mediating phosphorylation of Ser-81, Ser-94, Ser-308, Ser-515 and Ser-650.

Consistent with PLK mediating phosphorylation of Ser and Ser, we found that BI2536 and GSK461364 inhibited binding of βTrCP to overexpressed NUAK1.

We show that T3 induction of ROS activates CAMKK2 (calcium/calmodulin-dependent protein kinase kinase 2, β) mediated phosphorylation of PRKAA1/AMPK (5' AMP-activated protein kinase), which in turn phosphorylates ULK1 (unc-51 like autophagy activating kinase 1) leading to its mitochondrial recruitment and initiation of mitophagy.

Finally, we predicted the kinases which may mediate phosphorylation of these Atg proteins.

However, we and others previously showed that AGC kinases-mediated phosphorylation of Rictor at T1135 does not significantly affect mTORC2 complex integrity and its kinase activity (Dibble et al., 2009; Gao et al., 2010), which urged us to further examine whether the other mTORC2 essential component, Sin1, is a major target to mediate mTORC1/S6K's negative regulation of mTORC2.

Members of the JAK/Tyk family of tyrosine kinases mediate phosphorylation of STAT3 at Tyr705 and mTOR could mediate phosphorylation of STAT3 at Ser727.

Collectively, these studies suggest that Stk1 mediated phosphorylation of HU, SrdE and NWMN_1123 affects S. aureus gene expression and virulence.