Sentence examples for mediating neuronal damage from inspiring English sources

The role of HIV-1 transactivating protein, Tat has been elucidated in mediating neuronal damage via apoptosis, a hallmark of HIV-associated dementia (HAD), however the underlying mechanisms involved in enhanced neurodegeneration by illicit drugs remain elusive.

However, evidence supporting contributory roles of chronic inflammation as a causative factor in mediating neuronal damage in neurodegenerative diseases remains elusive.

In vitro studies further demonstrated that anti-INA Ab could mediate neuronal damage by inhibiting axonal elongation and driving the neurons to apoptosis.

First, we treated encephaltiogenic CD4 T-cells with nocodazole to disrupt the polymerization of microtubules required for the release of lytic granules and found that the treated supernatants failed to mediate neuronal damage (results not shown).

Several studies suggest that ERK activation mediates neuronal damage in pathological contexts (Subramaniam et al., 2004) and that ERK inhibition can be beneficial for normal neuronal survival and function (Ounallah-Saad et al., 2014).

A crucial role of MMPs in mediating neuronal death in the developing mammalian brain has been demonstrated in animal models for traumatic, ischemic, and epileptic brain damage [11],[11].

Guan, K. L. & Rao, Y. Signalling mechanisms mediating neuronal responses to guidance cues.

Hypoxic episodes or chronic hypoxia in the brain can lead to the generation of free radicals, an inflammatory mediated neurotoxic effect, and oxygen dependent enzyme, which mediate the neuronal damage.

Oxidative stress may mediate excitotoxic neuronal damage, resulting in an excessive stimulation of, for example, glutamate receptors [ 60] as well as the apoptotic death of neurons [ 61].

To further examine the link between motor neuron degeneration and DNA damage, we studied the expression of the transcription factor p53, which is known to be activated by multiple types of DNA damage and to mediate neuronal degeneration [ 34].

Moreover, VPA has been shown to mediate neuronal protection by activating signal transduction pathways and by inhibiting proapoptotic factors.