Sentence examples for mediating most of from inspiring English sources

It appears that NF- κB signaling in response to TLR4 stimulation is mediating most of the hypertrophic effects.

There are three protein isoforms of the GR (α, β and γ), of which GRα is the dominant form, mediating most of the actions of glucocorticoids.

Indeed, GFAP plays a role in mediating most of the signals involved in morphology and functional alterations observed during astrocyte activation.

In the prevalent component of the cancer MMI-network, mir-150 exhibits a leading role by mediating most of the mRNA/lncRNA connections.

This vasopressin receptor subtype is expressed in the kidney-collecting duct, mediating the antidiuretic action, and is also present in endothelial cells, mediating most of the non-renal effects of DDAVP, including a potent hemostatic effect [ 3, 4].

Drosophila melanogaster has a surprisingly small number of chemoreceptor genes, including just 62 odorant and 68 gustatory receptor genes [ 21], which appear capable of mediating most of their known chemosensory responses (reviewed in [ 22- 24]).

Interleukin-8 (IL-8) mediates most of the angiogenic activity induced by human oral squamous cell carcinoma (OSCC) cells.

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates most of the toxic effects of environmental contaminants.

Hence, EP1 might mediate most of the toxicity associated with cyclooxygenase-2 and contribute substantially to the cell death pathways in AD and stroke.

The additional diversity incrementally improved the affinities of antibodies raised against human vascular endoethelial growth factor and the structure of an antibody antigen complex showed that tyrosine side-chains are sufficient to mediate most of the interactions with antigen, but a glycine residue in CDR-H3 was critical for providing a conformation suitable for high-affinity binding.

The H1 receptor (H1R) mediates most of the proinflammatory effects of histamine.