This indicates that preparation conditions including temperature, pressure, and heating duration can largely mediate the molecular weight of sericin when it is extracted from cocoons.
Previous studies had attributed the proximal tubule reabsorption defects occurring in Lowe syndrome and Dent's disease primarily to abnormal endosomal recycling, such as for example the recycling of megalin, the scavenger receptor that mediates low molecular weight protein endocytosis, and CI-M6PR (Erdmann et al., 2007; Vicinanza et al., 2011; Mehta et al., 2014).
For example, tyrosine kinases, phosphotyrosine-recognition domains (SH2 s etc)., and also the ancestral forms of large multi-docking proteins with folded N-termini and long 'intrinsically disordered' tails, like the p130Cas, Gab or IRS family proteins [ 3- 5], which mediate high molecular weight signal transduction and integration complexes, emerged early during metazoan evolution [ 6].
These nonhydrolytic/nonenzymatic reactions mediated by low molecular weight compounds have been shown to enhance the activity of commercial cellulases and brown rot endoglucanases during hydrolysis of pure cellulose and various lignocellulosic substrates [ 79, 80].
Further, we proposed this harmful effect could be mediated by decreasing the molecular weight (Mw) of the polymer used to form the gel, while maintaining its gel-forming ability.
Low molecular weight compounds mediating pressure effects have been reported from a variety of deep-sea fish, invertebrates and microbes (Kelly & Yancey, 1999; Yancey & Siebenaller, 1999; Yin et al., 1999, 2000; Yancey et al., 2000, 2004; Yin & Yancey, 2000; Fiess et al., 2001, 2002; Martin, Bartlett & Roberts, 2002; Siebenaller & Garrett, 2002; Yancey, Blake & Conley, 2002; Yancey, 2005).
Freeze tolerance depends on the ability to restrict ice formation to extra-cellular areas, which is mediated by accumulation of low molecular weight carbohydrates in the blood [ 3, 34].
The maximum level of luciferase gene expression was mediated by transfection with a low molecular weight, high imidazole content (9400 Mw, 95 mol% imidazole) polymer.
Ferredoxin is a soluble low molecular weight protein that mediates transfer of one electron from a donor to an acceptor.
This study suggested that molecular weight of sericin mediates its secondary structure and assembly structure, which in turn leads to a control of final morphology of the electrospun materials.
