The DM signature contains two classes of genes required for cell proliferation: genes that maintain the integrity of mitotic chromosomes and genes that mediate mitotic division.
In dividing cells, paclitaxel impairs mitotic spindle function, causing a spindle assembly checkpoint-mediated mitotic arrest.
Our previous microarray analysis showed that CDCA3, referred to as a trigger of mitotic entry, mediates destruction of mitosis and the inhibitory kinase via the E3 ligase, SCF [ 10- 14] and was one of the up-regulated genes in the oral squamous cell carcinoma (OSCC -derived cells [ 15].
The major role of APC/C is to target substrates for proteasomal degradation in an orchestrated manner, with Cdc20 and Cdh1 mediating substrate recognition to ensure that mitotic entry and exit occur correctly.
Cell division cycle associated 3 (CDCA3), part of the Skp1-cullin-F-box (SCF) ubiquitin ligase, refers to a trigger of mitotic entry and mediates destruction of the mitosis inhibitory kinase.
Binding to PUM2 protects Aurora-A from the protein ubiquitination/degradation mediated by APC/CCdh1, and that is required for the dramatic increase in the kinase activity of Aurora-A, causing mitotic entry.
Here, we discuss the molecular processes of kinetochore assembly during mitotic entry and its disassembly during mitotic exit.
Petronczki, M., Lénárt, P. & Peters, J.M. Polo on the rise from mitotic entry to cytokinesis with Plk1.
The Cdk1 inhibitor Wee1 is inactivated during mitotic entry by proteolysis, translational regulation, and transcriptional regulation.
In addition, recent studies have suggested the Golgi-dependent control of mitotic entry.
