Doxo is known to increase ROS production, which can mediate mitochondrial damage and apoptosis in a p53-independent manner.
A reasonable explanation is anoxia-mediated mitochondrial damage and subsequent autophagy [ 9].
The mechanism of how the Beclin1-C fragment mediates mitochondrial damage requires further research.
In addition to mediating mitochondrial transport, kif5c plays a role in the mechanism of regulating mitochondrial morphology.
Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II.
Conversely, caspase-2 can mediate mitochondrial injury independently of Bak and Bax25,26.
LeBleu, V. S. et al. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.
Cao et al. have reported that the enzyme is a functional binding partner for BNIP3, known to mediate apoptosis and mitochondrial damage [ 23].
Low levels of GSH have been found to decrease resistance of cancer cells to chemotherapeutic drugs [43], boost cell apoptosis [44] and mediate ROS-induced mitochondrial damage [45].
A different form of cell death, necrosis, may contribute to HF, for example through mitochondrial damage mediated by increased cytosolic Ca2+ concentrations in cardiomyocytes.
