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Overall, the results warrant further exploration of mediating mechanisms of the effects of dexmedetomidine.
To further evaluate the role of PXR in mediating mechanisms of toxicity by CMP013, a subsequent 4-day toxicology study with CMP013 was carried out with wild type (C57Bl/6) and PXR-knockout (C57Bl/6NTac) mice (Table 1) to confirm that mice respond to CMP013 in a manner similar to rats.
Also needed are studies testing specific hypotheses concerning possible moderating and mediating mechanisms of the effects of interventions on distress and pregnancy outcomes.
17 Although family history has been shown to be associated with a twofold to threefold risk for developing SAD, 40 it is unclear which mediating mechanisms of genetic and environmental factors might be responsible for the variance in treatment effects.
23, 24, 33– 36 Whereas parietal regions are thought to be involved in the semantic representation of numerical magnitude, frontal regions are believed to play a role in mediating mechanisms of cognitive control and maintenance of a goal necessary for response selection.
However, the mediating mechanisms of epigenetics in cancer heterogeneity remain unclear.
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Besides providing additional support for previous findings, the major contribution of our findings is to highlight that occupational stress might affect risk for depressive symptoms in university teachers via a mediating mechanism of PsyCap.
We use genetic and pharmacologic strategies as well as in vitro culture approaches to define COX-2/prostaglandin receptor mediated mechanisms of action in eliciting synaptic and neuronal injury in models of human neurological disease.
Recently developed technology for DNA vaccination appears to offer the good prospect for the development of a multivalent vaccines that will effectively activate both the humoral and cell mediated mechanisms of the immune system.
The genetic composition of PAIs can shed light on the lifestyle of pathogenic bacteria, since they include virulence genes that mediate mechanisms of adhesion, invasion, colonization, proliferation into the host and evasion of the immune system [29], [30].
EDCs may exert adverse effects through a variety of mechanisms, including estrogen receptor (ER)–mediated mechanisms of toxicity (Fang et al. 2003b).
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