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Next, in order to give functional relevance to the above observations we looked at the ability of T cells co-cultured with RANTES or IP-10 conditioned BCG infected CFP10-DCs in mediating killing of BCG inside macrophages.
Recombinant retrovirus transformed CFP10-DCs induced 3-fold lower CFU than IFN-γ treated macrophages, indicating a better effect of conditioned DCs in mediating killing of M. tb inside macrophages than that observed with IFN-γ.
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The field of cancer immunotherapy has expanded rapidly in the past few years, with many new approaches entering the clinic for T cell mediated killing of tumors.
We then evaluated the effectiveness of drug-resistant immunocompetent cell mediated killing of tumor cells in the presence and absence of chemotherapy.
SEA/E-120 is likely to have a low toxicity due to its reduced capacity to mediate killing of MHC class II expressing cells.
In our endeavor to investigate the role of nitric oxide mediated killing of the P. vivax parasite in the An.
Our findings suggest that HLA-E is a key player in the regulation of NK cell mediated killing of ECs.
Blocking L-type and R-type VGCC in DCs, primed T cells that mediated killing of M. tuberculosis inside macrophages.
We extended the above observations to see if T cells recruited by RANTES and IP-10 would mediate killing of mycobacteria inside macrophages.
We first investigated whether, T cells activated by IFN-γ and IL-12 conditioned BCG infected CFP10-DCs would mediate killing of M. tb H37Rv inside macrophages.
We wanted to observe NK cell mediated killing of susceptible target cells within the silicon microwells using time-lapse, tile scan imaging to exemplify use of the chip as a tool to rapidly obtain many single cell events.
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CEO of Professional Science Editing for Scientists @ prosciediting.com