Sentence examples for mediating its phosphorylation from inspiring English sources

We investigated the response of αB-crystallin to oxidative stress and calpain inhibition in an attempt to elucidate the signalling pathways mediating its phosphorylation.

A possible mechanism for this action is that miR-143 down-regulates MAPK1, and increases PPARγ transcriptional activity by mediating its phosphorylation [ 32, 33].

It directly interacts with Dnmt1 and mediates its phosphorylation and it is involved in the structural organization and dynamics of nuclear speckles, suggesting that, like MeCP2, it might be implicated in the regulation of gene expression.

These combined data indicate that CK2 transiently interacts with the N-terminus of NEP to mediate its phosphorylation.

Interestingly, MAPK was shown to interact with Cx43 and mediate its phosphorylation, however, the effect of this phosphorylation on gap junction gating and function remains controversial [ 80].

PDK1 mediates its own phosphorylation, thus explaining why the protein expressed in bacteria is phosphorylated and fully active; most likely this phosphorylation proceeds by a trans-molecular mechanism [ 178].

The tyrosine kinases TrkC [ 39] and Src [ 40] also interact with BMPRII and could thus facilitate or mediate its tyrosine phosphorylation at sites required for the interaction to p55γ.

However, more recent studies suggest that Echinoid acts at the receptor in flies (Rawlins et al, 2003), and that EGF receptor physically associates with Echinoid and mediates its tyrosine phosphorylation when the two proteins are coexpressed in cultured cells (Spencer and Cagan, 2003).

mTOR mediates its action via phosphorylation of the eukaryotic translation initiation factor 4E (eIF-4E) binding protein (4E-BP1) disruptheg the integrity of these two components, which is essential for inhibiting cap-dependent mRNA translation, resulting in enhanced HIF-1 α protein translation (Fig. 3a).

(i) During the meiotic divisions, Rec8 phosphorylation mediates its separase-mediated cleavage.

Although we can't exclude the possibility that FASTKD2 mediates its apoptotic response through phosphorylation, it is likely that it initiates apoptosis via a different mechanism.