Sentence examples for mediating its phenotype from inspiring English sources

Nonetheless, the current reports from the Gould laboratory are consistent with Mcs5a mediating its phenotype through an immune surveillance mechanism within the mammary gland.

Interestingly, resistance to HER2/neu in situ carcinomas was not evident, indicating that Mcs5a is not acting during tumour initiation, but is acting during early mammary cancer progression [ 1], an observation consistent with Mcs5a mediating its phenotype through an immune surveillance mechanism.

The reintroduction of PRDX1 into breast cancer cell lines without its regulatory 3'UTR confirmed that miR-510 was mediating its migratory phenotype at least in part through the negative regulation of PRDX1.

Several aspects of the obesity phenotype appear to mediate its negative effect on bone health.

Here, we have investigated the role of TIEG1 in osteoclasts to further determine their potential role in mediating this phenotype.

Most studies of DAF-16 have focussed on its role in mediating the phenotypes of mutants of the C. elegans insulin/IGF like signalling (IIS) pathway.

Thus, the endothelium plays a key role in mediating the sepsis phenotype [14] and is a potentially valuable target of sepsis therapy.

Two ABC transporters have been identified as capable of effluxing Hoechst 33342 dye and mediating the SP phenotype in CSCs as well as normal cells; P-glycoprotein (MDR1) and breast cancer resistance protein (ABCG2) [18, 24, 25].

We thus conclude that neither thyroid hormone nor the GH signaling pathway is likely to be mediating the adipose phenotype.

The differential expression of these genes highlights the importance of these 4 genes over the other 53 genes in mediating the attenuated phenotype of H37Ra inside the host.

Roles of HMGA1 in mediating the malignant phenotype of this cancer are poorly understood.