Sentence examples for mediating its function from inspiring English sources

Furthermore, we found that AR also has an extensive role in negative gene regulation, with estrogen (related) receptor likely mediating its function as a transcriptional repressor.

Despite the well-documented anti-angiogenesis activity of 16 K prolactin, the receptor mediating its function remains to be identified, and the effect of acidosis on the function of 16 K prolactin is unknown.

79, 80 Interestingly, CD36 has four palmitoylation sites on both N- and C-termini, and it was shown that palmitoylation plays a crucial role in targeting CD36 to lipid rafts, where it mediates its function.

IL18 is another proinflammatory cytokine that shares many biological, structural and functional properties with IL1 [ 20] and mediates its function through its receptor IL18R (IL18R1 and IL18RAP).

It has been proposed that HLA-DM mediates its function by shifting the equilibrium of peptide averse to a peptide receptive state; however, the peptide loading process is still relatively undefined [14], [15].

IL-4 mediates its function by binding to receptors expressed on target cells such as T lymphocytes, and macrophages.

Metastin has been identified as a metastasis suppressor gene product that mediates its function through a G protein coupled receptor, GPR54.

By intercalation of organic polymers into the layered clay galleries, organic inorganic nanocomposites can be formed in which the clay framework serves to protect, stabilize and orient the polymer, and to mediate its function (Lu et al. 2001).

Accordingly, Hfq could be a candidate through which ClpX mediates its function in translational stimulation.

IL-1R1 is a signaling receptor for IL-1, which mediates its function [7].

However, genetic evidence suggested additional targets of PCFS4 that may mediate its function in both flowering time and leaf development.