MDM2 physically interacts with p53, thereby inhibiting its transactivation function, mediating p53 export from the nucleus, and inducing proteasomal degradation of p53.
Different from the β-catenin phosphorylation, NF-AT phosphorylation mediated by GSK-3β promotes its export from the nucleus, therefore terminating NF-AT-dependent transcription [ 18].
Cargo proteins exposing a NES are usually recognized and bound by CRM1, mediating the export towards the cytoplasm of cellular and viral proteins as well as ribonucleoproteins [12], [13].
Rev-RRE interactions regulate viral gene expression and genomic replication by mediating the export of incompletely spliced or unspliced lentiviral mRNAs from the nucleus to the cytoplasm of infected host cells [7], [9].
Notably, the ABC transporter YOR1, involved in mediating the export of many different organic anions including oligomycin, was also up-regulated 10.3-fold in pterostilbene-treated cells.
Although Sec24 has not been shown to have specificity for mediating integrin export, depletion of Sec24 isoforms with Sec24A having the most significant impact led to disruptions in ER export through decreased ability to recognize ER export signals on the ERGIC-53 cargo protein (34).
In human, TP53 is a tumor suppressor and JAB1 can enhance MDM2-mediated TP53 ubiquitination by mediating the nuclear export and cytoplasmic degradation of TP53.
Indeed, characterization of the kinetics of MCT4 reveals that it is especially suited for mediating export of lactic acid produced by glycolysis because, unlike MCT1, it has a very low affinity for pyruvate.
They probably do not serve only as anchors or transporters, although the possibility of noncovalent protein∶protein interactions mediating anchoring and export of non-attached "passenger" proteins cannot be excluded.
The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs.
