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We found it reduced UCP1 expression, but the SPR data confirmed it as a non-ActRIIB binder, so it is mediating its effects independently of the ActRIIB.
It is possible that NFAT-133 may be mediating its effects through some of these pathways since the compound did not significantly activate PPAR-γ.
To understand how Gal-3 could be mediating its effects, we analyzed C. neoformans gene expression in its presence and absence.
These data indicate that UCH L1 might be mediating its effects on migration via the AKT pathway.
ICP0 interacts with several cellular and viral proteins, ultimately mediating its effects by regulating gene expression, cell cycle progression and protein expression [16], [17].
Our finding of increased levels of IL-17A in gut mucosa, with no effect of Th17 cells in the spleen, suggests that cis-UCA may be mediating its effects through the γδ T cell subset.
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TGF-beta1, an anti-inflammatory cytokine, is upregulated following LPS stimulation, mediating its effect through SMAD family proteins.
SIAH2 appears to have several mechanisms of mediating its effect.
This observation suggests that Limk2 interacts with PlexinA1 in mediating its effect in semaphorin signalling.
Since HH signaling is received by mesenchymal cells, what is mediating its effect on NKX2-1?
This result suggests that RHA could be mediating its effect on the p53 IRES activity through its interaction with TCP80.
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