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Interestingly, a major adherens junction protein alpha-catenin, can also bind to and inhibit YAP by mediating its cell-cell junction and cytoplasmic localizations [ 33, 44].
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These results indicate that P-cadherin mediated adhesion or signals derived from its cell-cell interactions are indeed important determinants of mammary gland growth control and in the maintenance of an undifferentiated state during a specific period of time [ 34].
The Lewis X trisaccharide is pivotal in mediating specific cell-cell interactions.
HA has a great number of biological functions: it mediates cell-cell and cell-matrix interactions and plays an important role in cell migration, tumour growth and progression.
PECAM-1 is mainly expressed on endothelial cells where it mediates cell-cell contacts, vascular permeability, coagulation, and transmigration of leukocytes [ 32].
Although CEACAM1-S lacks tyrosine residues in its cytoplasmic domain, it also mediates cell-cell interactions[9], [21].
CD44 is a transmembrane glycoprotein with extracellular domains and has been implicated in mediating cell-cell and cell-ECM interactions and plays a role in cell migration [27].
For example, Drosophila auxilin exhibits specific genetic interactions with Notch receptors, mediating cell-cell interactions during development (Hagedorn et al. 2006).
Another group of cell surface molecules, namely cell adhesion molecules, are essential for mediating cell-cell interactions, and play an essential role in the process of angiogenesis (Telo et al., 1997; Petruzzelli et al., 1999).
E-cadherin is a metastasis suppressor gene mediating cell-cell adhesion.
N-cadherin associates with β-catenin at the apical end feet of radial glial cells, mediating cell-cell adhesion and polarity.
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