PGRN is a cysteine-rich protein and proper folding of the protein is critical to mediate its binding to TNFR.
Based on the studies showing that the 40s loop of CCL5 mediates its binding to glycosaminoglycans (GAG), we analyzed the roles of GAG in regulating CCL5 secretion.
These protein fragments are considered antibody-mimetic because, like antibodies, each protein fragment is composed of a constant region, which stabilizes the overall protein folding, and multiple variable regions that mediate its binding to a specific target.
Our study is the first to report the erythrocyte binding activity of PfRH2a/b and delineate a region of the native protein that mediates its binding with erythrocytes.
In conclusion, we have found that, despite the evolutionary diversification of the MAGE family, the characteristic hydrophobic surface shared by all MAGE proteins from yeast to humans mediates its binding to NSE4/EID proteins.
We have found that, despite the evolutionary diversification of the MAGE family, the characteristic hydrophobic surface shared by all MAGE proteins from yeast to humans mediates its binding to NSE4/EID proteins.
LBP binds to Gram-negative bacteria via the lipid A part of the lipopolysaccharide (LPS) which mediates its binding to the CD14 cellular receptor molecule presented by monocytes and macrophages [12], [13].
Our data also demonstrate that the N-terminal region of HIV-1 Vif mediates its binding not only to the target molecules A3G and A3F but also to A3C and A3DE.
Under physiologic circumstances, LBP binds Gram-negative bacteria via the lipid A part of LPS [ 14, 15], which mediates its binding to the CD14 cellular receptor molecule presented by monocytes and macrophages.
Similarly, the PHD domain of the HDAC-associated ING2 protein mediates its binding to the dimethylated and trimethylated H3K4 at the promoters of proliferation genes (Pena et al., 2006; Shi et al., 2006).
