Sentence examples for mediating its activation from inspiring English sources

With the discovery that ERK can be activated via the G protein and β-arrestin-dependent pathways, studies have revealed that the eventual cellular location of activated ERK is linked to the pathway mediating its activation.

In the present work, we seek to identify the responsive element within the BIK gene regulatory region mediating its activation by ∆Np73-α.

Several elements located upstream of the exon 1a of PUMA were also analysed, since they have been reported to mediate its activation by p73 [ 17].

GIT1 can anchor βPIX, which directly interacts with the small GTPase Rac1 and mediates its activation (ten Klooster et al., 2006).

Elevated phosphorylation of MTF-1 is observed under conditions of protein kinase C inhibition, suggesting that dephosphorylation of this transcription factor mediates its activation.

Actually, the PPAR is a key regulator of SCD which mediates its transcriptional activation [ 55].

Toluene's effect on 5HT3 receptors may be important in mediating its rewarding properties, as 5HT3 activation synergizes with systemic administration of ethanol in enhancing extracellular DA in the NAc (Campbell and McBride, 1995), and in alcohol-dependent individuals, ondansetron, a 5HT3 antagonist, reduces BOLD changes due to alcohol cues in the ventral striatum (Myrick et al, 2008).

Therefore our results suggest that GREM1 may be mediating its tumorigenic effect by the activation of a large transcriptional program.

The latent-transforming growth factor beta-binding protein 4 (LTBP-4) assists in TGF-β folding, secretion and activation by mediating its matrix targeting [ 36] and is also involved in cell adhesion and migration [ 37].

It is likely that it mediates its effect indirectly via activation of mast cells in the superficial airway to release mediators, which in turn activate local cough receptors.

Imiquimod represents a strong immune response modifier that mediates its effects via activation of toll-like receptor 7 (TLR 7), thereby resulting in an activation of NF-κB, elevated synthesis of proinflammatory cytokines and a potent increase of anti-tumor Th1 immunity.