Sentence examples for mediating its action from inspiring English sources

The present study was designed to test whether ethanol directly induced HMGB1 release and to explore the cellular and molecular mechanism mediating its action.

Although there is a general consensus about the crucial role of ERK in brain plasticity, little is known about the cellular mechanisms mediating its action(s).

Parallel microarray analysis has additionally identified a wide range of Pitx2 transcriptionally modulated left targets, possibly mediating its action.

It mediates its action through interaction with estrogen receptor (ER).

Bromocriptine is unique in that it does not have a specific receptor that mediates its action on glucose and lipid metabolism.

Insulin mediates its action on target organs through phosphorylation of a transmembrane-spanning tyrosine kinase receptor, the insulin receptor (IR).

The present study was designed to demonstrate that delphinidin, an anthocyanin that possess the same pharmacological profile than wine polyphenols in vascular protection, mediates its action via direct activation of ER-alpha receptor.

PGE2 mediates its action by interacting with four subtypes of PGE2 receptors, the EP1, EP2, EP3 and EP4 receptors [50].

One possibility is that HCRT mediates its action via HCRT target neurons in the pons since REM sleep is generated from there [9], [10].

PGE2 is reported to mediate its action by interacting with four subtypes of PGE receptors, the EP1, EP2, EP3 and EP4 receptors [50], but may also bind to the prostaglandin F (FP) receptor with an affinity that is only 10 30 fold lower than that of PGF2α [51].

Dopamine mediates its action via the 5 known dopamine receptors (D1-D5).