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The multisubunit transcription factor TFIID is essential for directing eukaryotic promoter recognition and mediating interactions with activators/cofactors during assembly of the preinitiation complex.
Families of conserved protein domains, specialized in mediating interactions with short linear peptide motifs, are responsible for the formation of a variety of dynamic complexes in the cell.
This has been shown to bind to phospholipids and may be responsible for mediating interactions with membranes [9].
These represent the three amino acids that were commonly identified as mediating interactions with the DNA substrate by three different studies [28] [30].
As a result, Chk1D469G is maintained in a functional state poised for mediating interactions with components of the checkpoint pathway albeit with reduced levels of phosphorylation and catalytic activity.
The 56 or more types of domains that we found associated with the remaining RNF E3s (Table 4) could play a variety of roles, including mediating interactions with substrate degradation signals (degrons).
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Therefore, Opa-negative meningococci harbour an additional adhesin mediating interaction with CEACAM1.
Calponin Homology domains (often arranged in 2 4 tandem repetitions) are well established as protein domains mediating interaction with actin filaments [12].
The fimbriae are essential for biofilm formation and mediating interaction with host cells while AafB has been implicated in epithelial cell invasion [62].
Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins.
Chromosome segregation requires assembly of kinetochores on centromeric chromatin to mediate interactions with spindle microtubules and control cell-cycle progression.
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