AUX1, which mediates influx of IAA into cells, was localized asymmetrically in the plasma membrane of certain cell types, facilitating directional auxin transport [ 69].
At high-dose ara-C (1 3 g m−2), however, hENT1 seems less crucial although plasma concentrations might not exceed the Km of the transporter mediated influx.
Our results do not exclude involvement of other P2XR since it is known that subtype receptors from the P2X family mediate influx of Ca2+ into stimulated cells [ 12].
Obtained results confirmed that the HCN2 channel indeed is mediating the influx of Ca2+ (Supplementary Figure S9A).
In agreement with this postulation, barley HvNIP2 1 (Hvlike), like rice OsNIP2 1 (OsLsi1), was demonstrated to function in mediating the influx of silicic acid in roots [ 9, 10].
Human copper transporter 1 (hCTR1) is the high-affinity copper influx transporter in mammalian cells that also mediates the influx of cisplatin.
Transporters mediate the influx of nutrients and excretion of metabolites in mammalian cells, playing a key role in the regulation of metabolism.
These results suggest that isolated, unmyelinated axons are vulnerable to hypoxic injury which is mediated by influx of sodium and calcium but is independent of glutamate receptor activation.
Importantly, the absorptive epithelial cells lining the lumen of the small intestine, the enterocytes, express several membrane-associated proteins which mediate the influx of luminal cholesterol and its subsequent efflux at their apical and basolateral sides.
As a Gq-protein-coupled receptor14, melanopsin acts via the activation of phospholipase C PLCC) and the production of inositol triphosphate (IP3), diacylglycerol (DAG) and subsequent activation of transient receptor potential canonical (TRPC) channels13,15, which mediate an influx of Ca2+ and Na+ ions16,17.
