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In addition to the potential role in adaptive immunity, recent reviews have described IL-23 as being 'primitive in origin' and have proposed a primary role in the evolutionary older innate immune system, particularly in mediating inflammatory attacks against pathogens of the intestine.
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COX-2 is an inducible enzyme mediating inflammatory responses.
p38 is involved in mediating inflammatory cytokine expression [18], [19].
IFNγ and TNFα are key pro-inflammatory cytokines mediating inflammatory events during several injury and pathological situations.
Factors mediating inflammatory responses outside the CNS likely play critical roles in CNS dysfunction.
CCR1 is a prominent receptor in mediating inflammatory leukocyte recruitment.
TNF-α is a central key cytokine that mediates inflammatory response.
Rheumatoid arthritis (RA) is an immune mediated inflammatory disorder, and immune suppressive drugs are prescribed.
TM (10 mg/kg) has significantly reduced the LPS mediated inflammatory responses.
The mechanism(s) by which CFTR mediates inflammatory signaling is under debate.
A chronic, T cell mediated inflammatory process determines the growth and development of atherosclerotic lesions [1] [3].
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