Sentence examples for mediating immunity to from inspiring English sources
There is, for example, strong evidence that major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs) play an essential role in mediating immunity to East Coast fever (ECF), a fatal lymphoproliferative disease of cattle prevalent in sub-Saharan Africa and caused by Theileria parva.
Macrophages, dendritic cells (DCs) and T cells are instrumental in mediating immunity to mycobacteria [4] [7].
In agreement, vaccine-induced IgG2 was previously found particular effective at mediating immunity to blood stage malaria infection in mouse models [44].
IL-17 is secreted by Th17 cells that comprise a recently recognized subset of T cells mediating immunity to extracellular organisms and being implicated in several autoimmune diseases [36].
Recently it was shown that ZAR1 interacts with the pseudokinase ZED1 in mediating immunity to P. syringae [ 57].
By challenging with a heterologous virus strain expressing different surface antigens, it is possible to significantly diminish the influence of antibodies in mediating immunity to secondary infection.
In addition to effects on phagosomal maturation, ManLAM has been shown to bind DC-SIGN, thereby suppressing DC maturation and skewing cell mediated immunity to interfere with induction of a protective anti-TB immune response (Geijtenbeek et al., 2003; Maeda et al., 2003; Tailleux et al., 2003; Wu et al., 2011).
These findings establish safe strategies for the enhanced generation of T cell mediated immunity to HIV-1 that can benefit in the design of an effective vaccine against AIDS.
This is consistent with a recent observation that CD4+ cell mediated IFN−γ production is required for optimal cell mediated immunity to B.anthracis [19].
These findings are relevant to current views that humoral factors operate antagonistically to limit cell mediated immunity to tumours.
Studies of immunologic function in lymphoma patients and cardiac transplant patients treated with immunosuppressive drugs have shown specific defects in cell mediated immunity to herpes viruses which may relate to their increased susceptibility to infection by these agents.
