Sentence examples for mediating hypoxic responses from inspiring English sources

2-ME inhibits Hypoxia Inducible Factor 1α, a transcription factor mediating hypoxic responses.

The central role of HIF-1α in mediating hypoxic responses has suggested new therapeutic opportunities, particularly in cancer and cardiovascular medicine [ 130, 131].

(6) H2S acts upon effector mechanisms known to mediate hypoxic responses.

Indeed, HIF-2 was suggested to mediate hypoxic responses under moderate hypoxia (5% O2), and HIF-1 may be stabilized at lower oxygen tension (reviewed in [27]).

Thus, as schematically summarised in Figure 7, the transcription factors HIF-2 and Ets-1 mediate hypoxic responses, whereas SP1 functions as a mediator of density effects.

In further exploring the mechanisms of hypoxic regulation and given the importance of miRNA mediated feedback loops in control of Dicer expression [ 41, 42], we examined possible influence of hypoxically induced miRNAs in mediating hypoxic repression of Dicer expression.

We have adopted a similar approach to the isolation of genes mediating hypoxic cell resistance.

The authors concluded that this suggests that angiotensin II does not play a role in mediating hypoxic pulmonary vascular tone.

We have identified cis-elements in the upstream regulatory region of the human endosialin gene that mediate the hypoxic responses and demonstrate that these elements bind HIF-2 in both direct and indirect manners.

Finally, similar to Mps1 [21], we show that during mitosis hypoxia changes the localization of Polo, suggesting a role for this protein in mediating the hypoxic response.

Besides HIF-1 α, HIF-2 α has also been reported to have a fundamental role in mediating the hypoxic response and GBM stem cell regulation.