Sentence examples for mediating hypoxic repression from inspiring English sources

In further exploring the mechanisms of hypoxic regulation and given the importance of miRNA mediated feedback loops in control of Dicer expression [ 41, 42], we examined possible influence of hypoxically induced miRNAs in mediating hypoxic repression of Dicer expression.

Of these genes, Redd1 is expressed in fetal distal lung epithelial cells; however, it does not appear to mediate hypoxic repression of mTOR in these cells (42).

2-ME inhibits Hypoxia Inducible Factor 1α, a transcription factor mediating hypoxic responses.

We have adopted a similar approach to the isolation of genes mediating hypoxic cell resistance.

In keeping with a role for the HIF hydroxylases in mediating this hypoxic repression, when cells were exposed to the HIF hydroxylase inhibitors, DMOG and desferrioxamine, a modest decrease in Dicer mRNA and protein levels was observed in MCF7 cells.

We therefore hypothesised that a hypoxically induced miRNA might mediate the hypoxic repression of Dicer expression.

The studies mentioned above suggest that there are many potential mediators and pathways that can mediate the hypoxic repression of hepcidin.

(6) H2S acts upon effector mechanisms known to mediate hypoxic responses.

How exosomal miRNAs might mediate hypoxic signalling requires further investigation.

Hypoxic repression and reaeration-induced transcription of genes for ATP synthase, cytochrome C oxidase and reductase, and NADH dehydrogenase suggest resumption of oxidative phosphorylation in reaerated MTB.

In keeping with a role for miR-103/107 in the hypoxic repression of Dicer expression, the blocking of miR-103/107 function abrogated the hypoxic repression of Dicer levels.