Sentence examples for mediating gene activation from inspiring English sources

ROS can directly reinforce passive barriers against pathogens - for example by chemically modifying plant cell walls - but are also important signal molecules mediating gene activation [28], [29].

MBD2 may also mediate gene activation because of its potential DNA demethylase activity.

A recent finding also suggests that MBD2 has potential DNA demethylase activity [ 13], implying that it might mediate gene activation in addition to transcriptional repression.

Studies with cultured cells using the WNT activated TOPFLASH promoter have identified many components that contribute to WNT mediated gene activation.

Here we utilize single-molecule observations of RNA in fixed and living cells to develop a single-cell model of steroid-receptor mediated gene activation.

Therefore, we analysed the 2 kb upstream promoter fragment to identify candidate transcription factor-binding sites that could mediate gene activation during differentiation.

By using the HIV-1 promoter to drive transcription of the viral genome during production, even if recombination does occur, the provirus should remain transcriptionally silent, reducing the probability of vector mobilisation, although the issue of enhancer mediated gene activation would remain.

If similar SIN deletion repair (i.e. repair not requiring sequence homology between the U3 region of the 5' and 3' LTRs) occurred in these vectors, transduced cells would contain a hybrid LTR with strong CMV derived enhancer elements, increasing the potential for both virus rescue/mobilisation and enhancer mediated gene activation [ 12].

These vectors contain a deletion in the 3' U3 sequence which is transferred to the 5' U3 sequence during reverse transcription, resulting in a provirus that contains no LTR derived enhancer or promoter elements [ 8], reducing the probability of proviral mediated gene activation.

Many, if not most, cytokines use the Janus kinase (Jak)–signal transducer and activator of transcription (STAT) signaling pathway to mediate gene activation or repression.

A specific cis-acting element of gene enhancer in CYP3A4 has also identified which confers HNF4α binding and permits PXR- and CAR-mediated gene activation [ 22].