Sentence examples for mediating firm from inspiring English sources

Indeed, leukocyte adhesion during inflammation is thought to proceed in a cascade-like fashion, in which selectins are responsible for leukocyte capture and rolling, and integrins for mediating firm adhesion and transmigration [ 5, 6].

ICAM-1 is an important surface receptor in the immunoglobulin family, which mediates firm adhesion of monocytes to endothelium.

This interaction would mediate firm adhesion of the leukocyte to the endothelium, aiding the inflammatory response post surgery.

In conclusion, our experimental data suggest that extravasated plasmin ogen) mediates firm adherence and (subsequent) transmigration of neutrophils to the reperfused tissue indirectly through activation of perivascular mast cells and a sequential generation of leukotrienes and PAF.

The extracellular region of ICAM binds ligands including fibrin, certain pathogens, and integrins of activated leukocytes, mediating their firm adhesion to endothelial cells.

Interestingly, although we initially saw a contribution of α4-integrins in mediating the firm adhesion of CD8+ T cells to the inflamed spinal cord microvasculature, this effect was lost mainly due to the low number of firmly adhering CD8+ T cells observed in the control group over time.

Separately, sLeX/P-selectin interactions support rolling and aICAM-1/ICAM-1 interactions mediate firm adhesion.

In particular, VCAM-1 mediates firm adhesion, tethering, rolling of monocytes and facilitates their transendothelial migration at the developing atheroma [26].

Endothelial ICAM-1 mediates firm arrest of rolling monocytes by binding to integrins LFA-1 and Mac-1 [45].

Leukocyte integrins and their ligands on endothelial cells, including intercellular adhesion molecules (ICAMs), then mediate firm leukocyte adhesion [ 20].

After injury ICAM-1 interacts with leukocyte integrins to mediate firm adhesion of activated neutrophils to endothelium and diapedesis [ 4– 7].