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In light of genetic evidence and an expression pattern consistent with a role in mediating features of dry AMD, we sought to determine if Suncr1-deficient mice displayed signs of degeneration of the outer retina.
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We next examined if Hsp27 mediates EMT features of BCSCs.
The conservation among microsporidians of these expanded families, against a strong background of reductive evolution, suggests that they mediate conserved features of host parasite interactions.
The presence of Tas1Rs in the airways is intriguing since hitherto these molecules were considered only to mediate positive features of ingested foods, i.e. the presence of carbohydrates (sweet) or amino acids (umami).
We have shown that the N-terminal tail of SpoIIE is necessary and sufficient for FtsH-dependent degradation and that stabilization in the forespore is mediated by features of SpoIIE that are required for interaction with the cell pole.
In mice, Mecp2 plays a key role as a transcriptional repressor in the basolaterol nuclei of the amygdala, mediating the behavioural features of Rett syndrome (Adachi et al., 2009).
Our results suggest that a small core of genes is responsible for mediating the similar features of dioxin hepatotoxicity in rats and mice but non-overlapping pathways are simultaneously at play to result in distinctive histopathological outcomes.
p53 mediates many features of DBA, but the mechanism of p53 activation remains unclear.
At first view, corresponding genes mediate general features of microorganisms and do not pose a potential risk regarding virulence.
Several clusters clearly represent gene sets that mediate specialized features of different cell types, including smooth muscle specific genes (cluster 40, Figure 2), B lymphocyte-specific genes (cluster 16, Figure 3), and genes selectively expressed in the testis (cluster 5, part shown in Figure 4).
This work represents the first report of specific structural features mediating functionality of the whole families of ALDHs in an organism ever characterized.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com