Sentence examples for mediating disruption of from inspiring English sources

Importantly, differences are exhibited between these systems reflecting those described in tissues, including a central role for tumour-associated fibroblasts and MMPs in mediating disruption of normal structures.

SCINDERIN has been reported to play a role in exocytosis by mediating disruption of F-actin cortical network, whereas the other members of the gelsolin family, such as gelsolin, contribute to cell motility.

Activation and liberation of such enzymes will undoubtedly mediate disruption of the endothelial glycocalyx.

A similar phenotype has been described for the HPV16 protein E5 [ 30], which mediates disruption of the exo- and endocytic trafficking, including transport of the MHC I [ 30], which causes reduced MHC I surface presentation and extends the half-life of the remaining MHC I molecules on the plasma membrane (M. R. Knittler, manuscript in preparation).

There was a distinct reduction in the initial rate of RNA synthesis in the presence of RapA (Figure 6B, compare lanes A1 and B1; see also Figure 6B, graph), likely due to RapA-mediated disruption of hypothetical tandem RNA polymerase complexes (Figure 6B, schematic).

These results confirm that BA-induced suppression of Sp1, Sp3 and Sp4 is linked to induction of ROS and ROS-mediated disruption of miR-27a:ZBTB10.

Adenoviral Cre-mediated disruption of mTOR expression in osteoblasts containing mTORflox/flox alleles, via an 83% reduction in mTOR mRNA levels, completely inhibited the effect of PTH on Hif-1α protein.

We therefore used this co-culture model system to investigate the potential involvement of MMPs and HGF signalling in mediating the disruption of normal architecture.

These data strongly suggest that the observed phenotypes were specifically generated by Dll-dsRNA, mediating the disruption of endogenous Dll mRNAs, in D. pulex.

Our preliminary evidence suggests a role for MMP in mediating the disruption of normal cellular interactions and demonstrates how these models could be used to dissect such interactions, as well as their potential for use in the identification and screening of novel therapeutic targets.

These features support the current opinion that the pituitary-associated headache is predominantly neurohumorally mediated by disruption of the dopamine prolactin axis in the presence of tumor [14].