We hypothesized that inherited variation in the ability to metabolize dietary PUFA may mediate development of CD and may have contributed to the previously observed inconsistent results.
Both hypovitaminosis D and diabetes affect cardiovascular factors and could further mediate development of CHD, as suggested by a study on 798 patients [ 63].
The expression of CTGF, which mediates development and secretion of ECM and plays a key role in HF development, was found to increase HSC activation.
Shahangian, A. et al. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice.
Huberman, A. D., Speer, C. M. & Chapman, B. Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.
However, the exact mechanism by which PARP-1 mediates development of these diseases needs to be better clarified in order for PARP-1 inhibition to be a potential target as a viable therapeutic strategy for cardiovascular disorders.
Microbiota-mediated development of regulatory circuits of TLRs and type I IFN seem to play a particularly important role.
Bone growth remodelling is a key mechanism mediating the development of the facial skeleton1,2,3.
Current evidence indicates that the acute locomotor stimulant effects of caffeine involve dopamine (DA) receptor activation; however, few studies have investigated the role of DA receptors in mediating the development of tolerance to caffeine.
Protein A is a well-characterized proinflammatory factor mediating the development of disease in the lung [23].
