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PTKs are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in metazoans.
So, although many macromolecules figure prominently in formation of cartilage and bone, specific CCN proteins appear to be key players in mediating development of cartilage and bone from first conception.
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We hypothesized that inherited variation in the ability to metabolize dietary PUFA may mediate development of CD and may have contributed to the previously observed inconsistent results.
The expression of CTGF, which mediates development and secretion of ECM and plays a key role in HF development, was found to increase HSC activation.
Both hypovitaminosis D and diabetes affect cardiovascular factors and could further mediate development of CHD, as suggested by a study on 798 patients [ 63].
Transforming growth factor-β (TGF-β) is a member of a superfamily of multifunctional cytokines which mediate development, wound repair, and other pathologic processes in many cell types [ 10].
In Figure 2, insulin-like growth factor-1 (IGF-1) encodes the protein involved in mediating growth and development.
Bone growth remodelling is a key mechanism mediating the development of the facial skeleton1,2,3.
We have presented some of the growing body of evidence for epigenetic mechanisms involved in mediating the development and maintenance of substance abuse.
Recent evidence has shown that these variables are critical regulators of diverse processes mediating embryonic development, adult tissue physiology, and many disease states, including cancer, atherosclerosis, and myopathies.
Within this context, we are further exploring the role of maternal factors, including substance exposure, maternal emotions, and physiological changes during pregnancy in mediating fetal development.
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