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From the TGN, multiple pathways to the endosomal system arise, mediating delivery of essential components to various endosomal intermediates.
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We recently showed that amphiphilic random copolymers based on the hydrophilic p N- 2-hydroxypropyl -methacrylamide), p N- 2-hydroxypropyl -methacrylamideed hydrop N- 2-hydroxypropyl -methacrylamideare able to mediate delivery of domp N- 2-hydroxypropyl -methacrylamideivo.
Interestingly, S. Typhi does not encode a homolog for the "B" subunit of the holotoxin, CdtA or CdtC, which mediates delivery of CdtB into target cells of the pathogens listed above [48].
The adapter protein p62 (SQSTmediatesates delivery of ubiquitinated cargo to autophagosomes.
The gene gun mediated delivery of a single gold microcarrier carrying the fEGFP expression plasmid results in the intense labeling of the whole dendritic tree as well as all dendritic spines of an individual pyramidal neuron.
Our data suggest that endogenous TbARL6 is associated with small vesicles throughout the parasite body and we speculate that TbARL6 could mediate delivery of the BBSome components on these vesicles.
Gene targeting was achieved by Adeno-associated virus (AAV) mediated delivery of targeting constructs essentially as described (Berdougo et al., 2009), except in the case if CAG/−cells (see below).
Because recombinant empty viral capsids are potentially attractive vectors for gene therapy, here we examined the ability of human papillomavirus (HPV) virus-like particles (VLPs) to mediate delivery and expression of DNA plasmids in vitro and in vivo.
Scherr, M., Battmer, K., Ganser, A. & Eder, M. Modulation of Gene Expression by Lentiviral-Mediated Delivery of Small Interfering RNA.
Grimsley, N., Hohn, T., Davies, J. W. & Hohn, B. Agrobacterium-mediated delivery of infectious maize streak virus into maize plants.
Toh WS, Spector M, Lee EH, Cao T. Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage.
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