Sentence examples for mediating degradation of from inspiring English sources

Essentially, SPARC acts as an anti-stress factor by mediating degradation of p53 through AKT-mediated MDM2 phosphorylation to promote melanoma cell survival.

Using a genome-wide RNA interference screen, the human F-box protein FBXO31 is shown to regulate the G1/S cell cycle transition in response to DNA damage by mediating degradation of cyclin D1, an important regulator of progression from G1 to S phase.

In a recent study, AtNLA1 was also involved in mediating degradation of NRT1.7 and further remobilizing nitrate from source to sink in Arabidopsis (Liu et al., 2016).

GRB10 also interferes with insulin signaling [31], [32], in part by mediating degradation of the insulin receptor [33], but the 3-fold increase in insulin receptor gene expression in women (Table 2) could serve to minimize any negative effect on insulin sensitivity that increased GRB10 expression might have.

These results reveal a role for HUWE1 in the invasion of lung carcinoma cells through mediating degradation of TIAM1.

Both a structural (AZC_0267) and a regulatory gene (AZC_0266) mediating degradation of the ethylene precursor 1-aminocyclopropane-1-carboxylate, are present in the genome.

The naphthalene dioxygenase (nahAc) gene is of particular interest as an indicator for PAHs degradation because the enzyme encoded by this gene not only degrades naphthalene, but also mediates degradation of other PAHs compounds [ 31, 34].

Autophagy is a complex catabolic pathway that mediates degradation of excess or unwanted cytoplasmic components through the lysosome.

This trafficking route would not result in the degradation of MHC-I, a phenomenon observed readily in other viral infections, such as Kaposi-sarcoma related herpesvirus infections, which mediates degradation of MHC-I by the K3 and K5 proteins46.

AGO-containing RISCs can then mediate degradation of complementary endogenous or viral RNAs, translational repression of mRNAs, or transcriptional silencing of transposons and DNA repeats.

Therefore, the crn-6 promoter is capable of directing the expression of NUC-1 to mediate degradation of bacterial DNA in intestine but the level of NUC-1 expression appears to be critical for this function.