Sentence examples for mediating death of from inspiring English sources

Our data indicates that pro-CASP8 is the apical caspase in the apoptotic pathway mediating death of casp9−/− cells exposed to prolonged ER stress.

Experiments with cultured IR macrophages loaded with lipoprotein-derived free cholesterol do show markedly increased apoptosis that suggest a key role of SRA-induced mechanism of ER stress in mediating death of IR macrophages [ 92].

As pneumolysin has been implicated in mediating death of various cell types, we examined the impact of pneumolysin expression on the viability of human DCs infected with T4 and mutants deficient in capsule and pneumolysin production.

In addition, the neurotoxic effects of FasL in the brain had been previously described in a model of chronic idiopathic demyelinating polyneuropathy, where macrophage-mediated demyelination was shown to be dependent upon FasL mediated death of Schwann cells [56].

A prevailing hypothesis is that ER stress-mediated death of pancreatic beta cells with a resultant loss of beta cell mass triggers diabetes onset in MIDY [23].

FAS and TCR restimulation mediated death constitute two of the major mechanisms regulating T cell survival and homeostasis [ 12- 14].

The CDK inhibitors flavopiridol and olomoucine also protected the neurons from these conditions, suggesting that these cell cycle elements might mediate death signalling as a result of DNA-damaging environments [ 4].

Gp120 has been proposed to mediate death of uninfected CD4 T cells; however whether gp120 kills resting CD4 T cells in the absence of activation is controversial.

The activation of autophagy in neutrophils mediates death of neutrophils, which results in decreased inflammation [ 89].

The molecules that mediate death of selective neurons in Alzheimer's disease (AD) are mostly unknown.

Indeed, Mst1 mediated FoxO3 activation in response to β-amyloid (Aβ) has been shown to mediate death of selective neuron in Alzheimer's disease (AD) [ 31].