This prediction disregards the possibility that mechanisms may exist which preferentially mediate connections of one direction over the other, thus leading to asymmetric connectivity profiles.
Importantly, BDNF is considered a key component mediating neuronal connectivity and movement dependent plasticity especially in the cerebellum [ 48, 49].
However, technical advances now provide the opportunity to understand the phenomena, at the level of detailed neural circuitry and molecules mediating functional connectivity.
Apart from mediating functional connectivity between a broad range of cells, facilitating intercellular transmission of electric signals or various cellular components, there is strong evidence for participation of NTs in pathological processes of particular medical interest.
Application of DCM to animal local-field potential data has facilitated validation studies, where independent, invasive measurements (e.g. microdialysis or pharmacological perturbations) suggest that DCM can be used to estimate the physiological mechanisms responsible for mediating effective connectivity [ 40 ].
Additionally, the ventral hippocampus mediates connectivity between the entorhinal/perirhinal cortices and the amygdala [34].
Both types of signaling enzymes are multiple domain proteins which often contain, in addition to their core catalytic function, multiple independently folding domains or motifs that mediate connectivity by interacting with other signaling elements [ 27].
Together, these findings support our proposition that cerebellar alpha oscillations may be the electrophysiological mechanism mediating neurotrophic-dependent connectivity changes resulting from sensorimotor training.
We found strong evidence of a well-defined effective connectivity architecture mediating the functional integration between the IPN and the inferior frontal cortices.
The influence of the extent of hydrogen bonding in mediating the long-range connectivity and percolation of the hard segment phase in model tri-segment oligomeric polyurethanes (PU) was explored by using LiCl as a molecular probe.
