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Finally, mediating connections among genes by using gene products means that a network can operate in an "environment" of exogenous gene products that influence its dynamic behavior.
Given the importance of SH3 domain adaptors in mediating connections between proteins at adhesion sites [37] we undertook a human proteome-wide SH3 domain phage-display screen using the cytoplasmic domain of β-DG as an affinity ligand, in order to identify potential adaptor proteins.
Whole brain data will be acquired and analysed for derivation of fractional anisotropy measures of white matter integrity and tractography of selected axonal tracts mediating connections between limbic and frontal regions of interest.
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Finally, vaccinating individuals with large betweenness centrality (frequency of mediating connection between pairs of individuals along the shortest paths) is superior to vaccinating ones with large connectedness to others or randomly chosen individuals, which was suggested by previous model studies.
This prediction disregards the possibility that mechanisms may exist which preferentially mediate connections of one direction over the other, thus leading to asymmetric connectivity profiles.
Provincial hubs provide structure within the local community, and connector hubs mediate connections between multiple communities.
SMA appears to mediate connections between language areas in the PT brain.
CAMSAPs mediate connections between microtubule minus ends and adhesion proteins at epithelial adherens junctions (Meng et al., 2008), and the synaptic-localized CAMSAPs we observed may play a similar bridging role at synaptic adhesion sites.
The major macrophage plasma membrane structures involved in this interaction are (1) receptors for the complement component 3 subunits C3b and C3bi, which bind to CR1 and CR3, respectively; (2) Fc receptors; (3) lectin receptors, which mediate connections with carbohydrate molecules; and (4) the integrin family of molecules that recognize specific amino acid sequences.
Shima and Tanji (1998) provide valuable evidence about the receptor types mediating descending connections to M1 from SMA, in comparison to ascending connections to M1 from S1.
Collectively, these observations imply that the N-terminal ectodomains of Pcdhs play a crucial role in mediating neuronal connections in the brain.
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Justyna Jupowicz-Kozak
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