Finally, loss of Ysp2p, Ysp1p or Sip3p reduces the rate of transfer of sterol from PM to ER, consistent with these proteins mediating a component of sterol transport.
c-Fos [3], cAMP response element binding protein (CREB) [16], a major downstream target for PTH/cAMP and calcium signals, cAMP-response element modulator (CREM [60], and Runx2 [23], [23], a master regulator of osteoblast differentiation and bone formation, have all been shown to mediate components of the PTH anabolic response.
In its GTP-bound state, Ras is able to interact with its downstream effectors, and mediate some component of Ras' cellular actions through complex signal transduction cascades (Fig. 1).
Due to the functional significance of the SH2 domain in mediating multiple components of the STAT signalling cascade, many libraries of inhibitors have been designed to target the SH2 domain.
Owing to the role of VEGF in mediating multiple components of the tumour microenvironment, mechanisms of acquired resistance are complex and multi-factorial.
We show that EPSP generation consists of activation of both AMPA and NMDA receptor channels, which mediate distinct components of the recorded field potential.
However, GluMIs and type 2 OFF bipolar cells possess functionally distinct light-driven responses and may therefore mediate separate components of the excitatory synaptic input to AOFF-S RGCs.
Influenza-induced ARDS, which involves the damage to the epithelial-endothelial barrier of the pulmonary alveolus, flute leakage to the alveolar lumen, and respiratory insufficiency, is associated not only with direct viral damage to epithelial-endothelial barrier, but also with inflammation mediated by components of the innate immune response.
Basal apoptosis was mediated by components of the TNFα response pathway but was mechanistically distinct from TNFα-induced apoptosis.
Increases in the size of the prefrontal cortex in particular, which mediates important components of complex social behavior such as planning, working memory, memory for serial order, and language may have played an important role in human brain evolution [6].
