Sentence examples for mediating cochlear damage from inspiring English sources

There is increasing evidence for a role of TLRs in mediating cochlear damage in meningitis [ 15].

The iron species bind to aminoglycosides to produce a toxic complex, which mediates cochlear cell death via apoptosis (figure 1C).

Our results are the first to show that cisplatin-induced cochlear damage and hearing loss are mediated by the significant decline in SIRT1 activity by a decrease in intracellular NAD+ level because of the hyperactivation of PARP-1 and the decrease of SIRT1 expression regulated by the p53-miR-34a p53-miR-34a p53-miR-34a

Pneumolysin interferes with the beat frequency of brain ependymal cilia [ 25], damages the blood-brain-barrier (BBB) [ 26], mediates apoptosis of microglial and neuronal cells in vitro[ 27] and participates in hearing loss and cochlear damage associated with experimental PM [ 28]; moreover, a pneumolysin-deficient mutant showed reduced virulence in murine PM [ 29].

Dong, W. and Olson, E.S. 2010 "Local cochlear damage reduces local nonlinearities and decreases generator-type cochlear emissions while increasing reflector-type emissions.

Thus, understanding endogenous cell signaling systems involved in cochlear protection may lead to new strategies and therapies for prevention of cochlear damage and consequent hearing loss.

The results reported in this study indicate the importance of specialized treatment in children affected with recurrent acute otitis media to prevent cochlear damage.

There is increasing evidence that TLRs contribute to cochlear damage in meningitis [ 15].

This research provided evidence that intense noise can initiate ROS generation, resulting in cochlear damage.

Therefore, oxidative stress may be an important mechanism in therapy-related cochlear damage.

Two main pathways result in cochlear damage following noise exposure: mechanical damage [ 86] and biochemical pathways triggering apoptosis or necrosis.