Sentence examples for mediating cleavage of from inspiring English sources

Designed to simulate miRNAs, small interfering RNAs represent a powerful genetic approach to potently inhibit gene expression by mediating cleavage of the intended mRNA target.

Cathepsin S activity is normally restricted to the lysosomes of professional antigen presenting cells, mediating cleavage of the invariant chain from MHC class II complexes prior to antigen loading for presentation [9], [10].

Owing to the observed interaction network, we presume that Ser309, Lys334, and Gln338 function as catalytic triad mediating cleavage of the 4FA substrate.

We identified approximately 200 potential piRNA target sites on specific mRNAs, thus implicating piRNAs in mediating cleavage of these mRNAs in mouse male germ cells.

However, when the fusion protein of EspZ with β‐lactamase (EspZ-TEM) translocates into HeLa cells via the T3SS of WT EPEC, it mediates cleavage of CCF2‐AM, which induces a shift from green to blue fluorescence (460 nm).

This is consistent with a previous study that caspase-3-mediated cleavage of p21 during the apoptotic process sends growth-arrested cells to apoptosis[72].

CTSD subsequently mediates cleavage of Bid leading to activation of caspase-9 and -3.

Thus, cathepsin D mediated cleavage of Aven is unlikely involved in the regulation of translational control described herein.

Our in vitro experiments showed that HD PMNLs can mediate cleavage of VE-cadherin from endothelial cells.

The small RNAs are created through the action of the RNaseIII, DICER, and both can mediate cleavage of complementary RNA through a multi-protein RISC-complex [ 24].

MicroRNAs (miRNAs) are regulatory small RNAs produced through DICER-LIKE1 (DCL1)–mediated cleavage of the stem-loop structure of primary miRNA precursors (pri-miRNA) (Kurihara and Watanabe 2004; Song et al. 2010).