Sentence examples for mediating cellular stress from inspiring English sources
Apart from its intrinsic interest with respect to the complex mechanism of aB-crystallin gene expresssion [38], [39], AhR regulation of the αB-crystallin gene is biologically logical: both αB-crystallin and AhR function in mediating cellular stress responses [39], [40].
The distinct transcriptional activities of those genes may indicate their complementary roles in mediating cellular stress responses.
Importantly, our results continue to build on the numerous studies now supporting a role for miRNAs in mediating cellular stress responses (Leung and Sharp, 2010; Mendell and Olson, 2012).
The p53 tumour suppressor protein, often referred to as the ' guardian of the genom', plays a critical role in mediating cellular stress responses such as that brought about by DNA-damage, and is therefore key in regulating a vast array of proteins involved in cell cycle progression and check-points, DNA repair and apoptosis [ 1].
Further reports have shown that under conditions of cytokine deprivation mediated cellular stress, AKT-mediated activation of FOXO3A and subsequent transcriptional regulation by FOXO3A leads to cell cycle arrest and apoptosis [54], [55].
As central integrator, PARP1 may mediate cellular stress response pathways and thereby participate in a multitude of age-related pathologies.
A critical component of the HPA axis which mediates cellular stress responses in the OFC, and has been implicated in psychiatric illness, is the glucocorticoid receptor (GR).
The P53 pathway has been shown to mediate cellular stress responses, inducing cell-cycle arrest, senescence, and apoptosis [34].
However, as FOXO factors also mediate cellular stress resistance, they might also increase resistance to chemotherapeutics.
Owing to its tissue protective properties S1P turned out to be primarily a survival signal, whereas ceramide was shown to mediate cellular stress response.
H2O2 causes to release of Ca2+ flux into the cellular matrix, which is the control point for signal transduction processes or activates some members of the mitogen-activated protein kinase (MAPK) family-central for mediating cellular responses to stresses (Neill et al. 2002).
