Sentence examples for mediating cellular stemness from inspiring English sources

Another example of a protein with chromatin remodeling activity required for mediating cellular stemness is chromodomain helicase DNA binding protein 1 (CHD1), which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA.

Proinflammatory cytokines play a central role in mediating cellular and physiological responses.

EGR1 is an early response gene and can mediate cellular responses to mitogens and growth factors.

Qiu, Y. et al. Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods.

These nuclear receptors control expression of proteins that mediate cellular cholesterol release including apoE.

TxA2 may also mediate cellular hypertrophy [ 68].

ROS can mediate cellular damage through direct interaction with cellular components.

These data suggest that Akt-mediated phosphorylation of Oct4 on T235 might regulate cellular stemness in a signal dependent manner through modulating heterodimer formation with Sox2.

Altogether, these observations suggest that HDACs class IIa and, in particular, the HDAC4 play key roles in determining responses to radiation-induced DNA damage and in maintaining cellular "stemness", thus promoting radioresistance.

Unfortunately, it is not yet clearly known whether the cellular stemness in other cancer types is maintained by the downstream intracellular signaling of CD133 (Su et al., 2015).

These mechanisms synergize to choreograph cellular stemness and to generate cellular diversity.