Sentence examples for mediating cellular damage from inspiring English sources

In the present study, we investigated whether mitochondria are the potential cytoplasmic target of high LET radiation in mediating cellular damage using a mitochondrial DNA (mtDNA) depleted (ρ0) human small airway epithelial (SAE) cell model and a precision charged particle microbeam with a beam width of merely one micron.

ROS have been known for a long time to induce cell cycle alterations; however, focus was directed towards secondary effects mediating cellular damage [ 51].

In conclusion, our data provides evidence that plasma histones are not only elevated in human sepsis but are associated with sepsis-related organ dysfunction, mediating cellular damage and severe inflammation responses.

Depletion of NK cells before immunization resulted in significantly less severe EAU, demonstrating that NK cells participate in the development of EAU, either by directly mediating cellular damage or by supporting rather than suppressing autoreactive T cells [ 84].

ROS can mediate cellular damage through direct interaction with cellular components.

Hence, converging lines of evidence indicate that mTOR and its downstream pathway, by transducing nutrient-triggered signals, may mediate cellular damage, through molecular mechanisms largely involving mTOR cross-talk with growth factor-triggered mitogenic and survival cascades.

Oxidative stress triggered by the increased production of ROS and nitrogen reactive species could mediate cellular damages in tissues such as in the heart, brain and liver (Goldbart et al. 2003; Haussinger and Schliess 2008; Joyeux-Faure et al. 2005).

Diverse spectrums of cellular changes that underline dysfunctional signal transduction are attributed to mediate cellular damage associated with their use [ 32].

Lipids, DNA, and proteins have been shown to interact with ROS and mediate cellular damage [ 46], given that it is not surprising that chronic and acute exposure to excessive levels of ROS can induce cell death processes (apoptosis, necrosis, and autophagy) [ 47– 50].

Here, we demonstrate that in response to cellular stresses such as DNA damage, PRAP1 expression is significantly induced by p53, a key player mediating cellular responses to DNA damage.

Functionally, the ATM protein is a pivotal player in mediating cellular responses to DNA damage, including DNA double-strand break repair and signaling, leading to cell-cycle arrest and apoptosis (reviewed in Rotman and Shiloh, 1999).