Using cell aggregation assays and gamma-secretase inhibitors we show that Wry is a novel Notch ligand that can mediate cellular adhesion with Notch expressing cells and transactivates Notch to promote signaling and nuclear transcription.
Furthermore, CfLec-2 could mediate cellular adhesion to enhance encapsulation of hemocytes, which was similar to CfLec-1, but it could not mediate phagocytosis [53].
CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration.
As a cell adhesion molecule, CD44, a widely expressed cell-surface glycoprotein and a cell-surface receptor for hyaluronate and osteopontin, is known to mediate cellular adhesion to the ECM, which is a prerequisite for tumor cell migration [ 2].
Therefore, β-catenin-dm maintains the ability to mediate cellular adhesion and, likely, to de-repress TCF targets, allowing the identification of effects of β-catenin that are TCF-transactivation independent.
This fusion protein coating, which mediates cellular adhesion through the E-cadherin component, has been reported to support long-term culture of teratoma-forming hPSCs in combination with a range of chemically defined media and has been commercialised as StemAdhereTM[ 10, 43].
Integrins are the major receptors that mediate cellular adhesion and reaction to the ECM and thus play essential roles in regulating cell migration, growth, division, survival, differentiation, and apoptosis.
These proteins collectively mediate cellular adhesion to extracellular matrix (ECM) and modulate cell proliferation, migration, invasion, and survival by activating intracellular signaling pathways [ 11].
Claudins, the major tight junction transmembrane proteins, are members of the tetraspanin protein superfamily that mediate cellular adhesion and migration [ 64].
