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It was observed that high Young's modulus scaffolds are always less invaded than softer ones, confirming the role of the 3D micro-environmental stiffness in mediating cells migration, including when specific functionalization or pharmacological treatments are performed.
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To investigate the functional requirement for CAM-1 domains in mediating cell migration, we engineered deletions that remove various domains and assessed the ability of these CAM-1 derivatives to rescue cam-1 mutant phenotypes.
FAK plays a central role in mediating cell migration [38], [46], [47].
This implies that moesin is not the exclusive tool mediating cell migration and invasion in the presence of this PR agonist, which is not surprising.
Thus, the inclusion of the tags does not appear to compromise coupling of the receptor to downstream elements responsible for mediating cell migration.
A number of studies have underscored the importance of ILK in mediating cell migration and invasion.
Src-transformed CEFs are highly motile and characterized by structures mediating cell migration called podosomes [ 78, 79].
A central part of CTGF's role in endothelial cell function and angiogenesis may involve direct interaction with integrins in mediating cell migration and to avoid cell death.
Integrins represent a large family of heterodimeric transmembrane receptors that connect the extracellular environment to the intracellular cytoskeleton, thus mediating cell migration, proliferation, survival and differentiation [40].
However, the complex set of morphological rearrangements that occur during gastrulation make it difficult to uncouple the role of specific signals in mediating cell migration from those acting directly on cell specification (Villegas et al., 2010).
Since AAH has a demonstrated role in mediating cell migration, which is needed for proper cerebellar foliation, reduced AAH expression in brains of siAAH-transfected rats could account for the associated perturbations in cerebellar architecture.
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