The following review describes published reports of defined culture surfaces for hPSC self-renewal with a focus on the CAMs and extracellular matrix proteins (ECMPs) thought to be involved in mediating cell-surface interactions and maintaining pluripotency.
The Siglec family of receptors mediates cell surface interactions through recognition of sialylated glycoconjugates.
In addition, the P aeruginosa type IV pilus mediates cell surface translocation by a process known as twitching motility.
CNTN1 is known to mediate cell surface interactions in the development of the nervous system by signaling between axons and myelinating glial cells [ 53] and has been shown to promote cellular adhesion and invasion of lung cancer cells [ 54].
Transmembrane domains derived from CD28 were utilized to mediate cell surface expression of MESA, which is an approach used extensively for this purpose in fusion proteins such as chimeric antigen receptors (CAR).
Although CBM37-encoding ORFs did not show homogenous phylogenetic affiliation to Flavobacteriales by the LCA algorithm applied, it is still plausible that some unknown species of Flavobacteriales also mediate cell surface attachment via CBM37-like domain; and further genome recovery is required to validate this speculation.
CHL1, located at 3p26.1, belongs to the family of cell adhesion molecules (CAM) – cell surface proteins mediating cell-cell and cell-matrix interactions.
Furthermore, S. aureus nasal colonization is characterized by the expression of genes mediating adhesion, cell surface dynamics/remodeling, the expression of immune evasion genes and the lack of toxin transcription.
A recent study [ 28] suggested that the mechanism by which normal HFE protein regulates hepcidin expression is by binding intracellular ALK3 and mediating its cell surface localization.
CPMV was previously shown to interact with vimentin displayed on cell surfaces to mediate cell entry, but the expression of surface vimentin on APCs has not been characterized.
Although the major effects of COX-derived lipid mediators are mediated through cell surface receptors, some prostanoids and their metabolites may act on target cells through nuclear receptors located at the nuclear envelope [ 50].
