Sentence examples for mediating cell motility from inspiring English sources

TNC has been also implicated in mediating cell motility and invasion in a variety of epithelial cancers.

Previous work in our lab suggests a role for IRS-2 in mediating cell motility in highly metastatic breast cancer cell lines (Jackson et al, 2001).

HMMR is a multicompartmentalized receptor for the extracellular matrix carbohydrate HA with potentially oncogenic functions such as mediating cell motility and affecting mitotic spindle integrity [ 35].

It was immediately apparent that several of these targets play critical roles in mediating cell motility, prompting us to speculate that these families of miRNAs specifically target genes involved in this biological process.

Substantial evidence has been culminated to support the key role of c-MET/HGF signalling in mediating cell motility and cytoskeletal functions in SCLC (Maulik et al, 2002a, 2002b; Ma et al, 2003a).

Future studies aimed at exploring the mechanism of regulation of miR-25/32/92abc/363/363-3p/36 and miR-99ab/100 miRNA families in the presence of β4, as well as the role of putative targets in mediating cell motility downstream of this integrin, will provide further insight into the role of β4 function in promoting carcinoma progression.

PI3K can mediate cell motility through the activation of small GTPases.

The same group also determined a role for XIAP RhoGDI interaction via RING domain of XIAP to mediate cell motility by regulating actin cytoskeleton.

S1Pext mediates cell motility through activation of Rac1 and IQGAP1 signal transduction in HPAECs.

Nexilin is a F-actin binding protein and mediates cell motility, over-expression of which promoted cell migration and adhesion[46].

In single cells, syndecan-1 activates formation of filopodia and lamellipodia that mediate cell motility [ 12, 13].