Sentence examples for mediating cell gradient from inspiring English sources

A previous modeling study examined the role of ligand-induced homologous receptor desensitization in mediating cell gradient sensing [25].

The current simple 2-D model has the potential to be further developed to consider the downstream signaling pathways such as G-protein signaling for mediating cell gradient sensing and migration.

To overcome this limitation, in the present study, we further develop the model to test the role of ligand-induced homologous receptor desensitization for mediating cell gradient sensing in two-dimensional (2-D) ligand fields, and we performed computer simulations for the dynamic cell migration process in different configurations of ligand gradient fields.

Because cell gradient sensing in the steady state and the dynamic cell migration process are fundamentally different, our study not only improves the previous modeling study to test the role of receptor desensitization in mediating cell gradient sensing in 2D, but more importantly explores the importance of this mechanism for effective migration in complex gradient fields.

To further understand the observed repulsive migration of cells from the CCL19 gradient in the uniform background of CCL21, we adapted a previous mathematical model to consider the ligand-induced chemoattractant receptor modulations for mediating cell orientation and migration in ligand fields [28].

Fibronectin also mediates cell migration.

Finally, further modeling of cross receptor desensitization by competing ligand gradients will provide more insights into the receptor desensitization mediated chemotactic guiding mechanisms for cell gradient sensing and cell migration.

Given the results that nondesensitizable receptors mediate cell orientation and migration in single ligand gradients at a higher level, we further test the influence of receptor desensitization on gradient sensing and migration in competing ligand gradients.

P3-25 potentiatedifferentnt chemotherapeutic agents-mediated cell death.

CXCR3 expression in human and murine melanoma cell lines has been suggested by others to mediate directional cell migration along the chemokine gradients of CXCL9, CXCL10 and CXCL11 (Robledo et al, 2001; Kawada et al, 2004).

The chemotaxis is mediated by cell adhesion molecules towards a gradient of chemokines.