Sentence examples for mediating cell cycle from inspiring English sources

Although the striking increase in p21 protein levels upon R1881 exposure and the known role of p21 in mediating cell cycle arrest suggested that p21 might be a key mediator of AR-induced arrest, we sought to definitively confirm this using two complementary techniques: knock-down of p21 gene expression via RNA interference (RNAi), and somatic cell gene knock-out, as described previously [ 61].

In addition to the canonical tumor suppressor activities of p53 in mediating cell cycle arrest, apoptosis and senescence, p53 can also function in maintaining tumor dormancy via suppression of angiogenesis [32].

This paper elucidates a model to regulate glioma cell cycle progression in which hUCBSC acts to control cyclin D1 induction and in concert its partner kinases, Cdk 4 and Cdk 6 by mediating cell cycle arrest at G0-G1 phase.

Carcinogens may induce tumourigenesis partly by mediating cell cycle malfunction.

The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress.

Until recently, however, the mechanisms responsible for mediating cell cycle entry in primary MM cells were not known.

Regarding the adult liver-enriched miRNAs, similar to let-7, miR-23b is capable of inhibiting cell proliferation [44], and may mediate cell cycle arrest in mature hepatocytes.

ATM kinase also mediates cell cycle checkpoints and DSB repair by HR or NHEJ, depending on the DSB end structure and on the cell cycle at the time of damage [13], [14].

Since cells progressing through mitosis are less adherent to culture dishes, this technique provides a way to synchronize cells in the absence of any drugs to mediate cell cycle arrest.

Gadd45 proteins interact with many effectors, including Cdc2/CyclinB1 [5], [5], PCNA [6], [7], p21 [8], nuclear hormone receptors [9], histones [10] and MEKK4 [12], [12], to mediate cell cycle arrest, differentiation or apoptosis.

Let-7 family members have been shown to target proliferation-promoting genes, such as HMGA2 [37] and IGF2BP1 [39], and as such, may mediate cell cycle arrest in the adult liver.