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In addition, peptides mediating binding to the cell type of interest can be identified by random phage display library screening and subsequently be introduced into an AAV capsid region critical for receptor binding.
In humans, the liver synthesizes solely the full-length form of apolioprotein B (APOB), called APOB100, which contains in its carboxy terminal region the motif mediating binding to LDLR.
EBA-175 was the first protein identified to be involved in the junction formation between merozoite and RBC mediating binding to the receptor glycophorin A (reviewed by Gaur et al. [1]), followed by EBA-175 paralogues such as EBA-140 and EBA-181 binding to glycophorin C or unknown receptors [9].
Alternatively or in addition, peptides mediating binding to the cell type of interest can be identified by random phage display library screening and subsequently be introduced into an AAV capsid region critical for receptor binding [6], [7], [8], [9], [10], [11], [12].
However, this region is responsible for mediating binding to aIF2γ through a MoRF-type interaction.
Thus, the PAM2 motifs of TNRC6A C are essential in mediating binding to both Hs and DmPABPC1.
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IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins.
These residues are predicted to mediate binding to proteins bearing a region called a PDZ domain.
Moreover, RCL appears to mediate binding to a cell surface receptor that promotes cell adhesion to type I collagen and fibronectin [12, 13].
Recently it was shown that Cyt2Aa specificity could be modified to kill aphids by the insertion of a peptide sequence, in exposed loop regions, that mediates binding to an aphid APN (Chougule et al. 2012).
Both structures serve to mediate binding to nuclear transport proteins.
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mediating adherence to
mediating tolerance to
mediating relapse to
mediating committee to
mediating transport to
mediating susceptibility to
mediating washback to
mediating adhesion to
mediating bioadhesion to
mediating resistance to
mediating sensitivity to
mediating attachment to
mediating immunity to
mediating response to
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