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Binding of Y12, N13 and M20 involved the same residues mediating binding of 24112 to HLA-DRβ1*0403 in Ao191, but displayed a totally different H-bonding pattern in the 24112 HLA-DRβ1*0422 complex between V15 with Pocket 4 Glnα9 (in dark blue, 2.27 Å), and R17 with Pocket 6 Lysβ71 (in brown, 1.71 Å).
In this paper, we report that YadA confers a high level of sensitivity to killing by PMN-produced NETs to Yersinia, by mediating binding of the bacteria to NETs and thereby rendering them accessible to the AMPs present on the NETs.
Among the latter, - 7-iso-jasmonoyl isoleucine (JA-Ile) was demonstrated to be the biologically active form of jasmonates by mediating binding of the co-receptor proteins CORONATINE INSENSITIVE1 (COI1) and JASMONATE ZIM DOMAIN (JAZ) [ 10- 13].
It is essential for clathrin trafficking, mediating binding of clathrin to the plasma membrane and the trans-Golgi network, and regulating receptor signalling by influencing trafficking downstream of clathrin-coated vesicles [ 3, 4].
Since very low levels of α-actinin may not be detected by the above methods, further experiments were devised to rule out the surface expression of the protein or its role in mediating binding of Opc+ bacteria to target cell surfaces.
The common features of RBDs of spike proteins of SARS-CoV, influenza virus and Hendra virus include: (i) being located in the spike proteins; (ii) mediating binding of the virus to the target cell via the interaction between viral spike protein and the receptor on the target cell; (iii) having a length ranging from 30 to 215 aa; and (iv) containing discontinuous neutralizing epitope(s).
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Plasmodium falciparum-mediated pathogenesis has been associated with the parasite's ability to mediate binding of its host cell to the vascular endothelium of several organs, notably the brain leading to complications such as cerebral malaria.
The NTR domain also mediates binding of PCPE-1 to cells, an interaction inhibited by heparin, thus suggesting involvement of cell membrane heparan-sulfate proteoglycans (HSPGs).
In particular we focus on the structures of two molecules; the erythrocyte binding antigen, EBA-175 involved in erythrocyte invasion and the VAR2CSA protein that mediates binding of infected erythrocytes to the placenta.
The C-terminal end of Clr4 harbors a SET domain responsible for the enzyme's catalytic activity, while the N-terminal domain contains a chromodomain region that mediates binding of the enzyme to H3K9 methylation groups (Min et al., 2002; Zhang et al., 2008).
Mesangial cells express FcγRs and may mediate binding of IC by recognition of exposed Fc-part [41].
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mediating suppression of
mediating transport of
mediating mechanism of
mediating recovery of
mediating activation of
mediating chemoresistance of
mediating effect of
mediating expression of
mediating dilation of
mediating layer of
mediating endocytosis of
mediating folding of
mediating induction of
mediating assembly of
mediating reabsorption of
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