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The pilus-associated adhesin PilC1 plays a critical role in mediating attachment to host epithelial target cells [22], [23].
The bacterial surface provides the first barrier against innate immune mechanisms as well as mediating attachment to cells/surfaces to resist clearance.
Moreover, the dorsal and ventral haltere surfaces remain separate throughout development, with integrins mediating attachment to the central haltere matrix rather than dorsal cells.
Such structures have also been implicated in mediating attachment to human epithelial cells [9], [24], [25], in the adhesion and invasion of brain microvascular endothelial cells [26] and in promoting transepithelial migration [27].
The PI-2a GBS pili have also been implicated in mediating attachment to human epithelial cells [16], [26], [27], in biofilm formation [26], [28], in the adhesion and invasion of brain microvascular endothelial cells [29], and in promoting transepithelial migration [30].
Type IV pili are known to act as adhesins for P. aeruginosa, mediating attachment to epithelial cells (Hahn, 1997).
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The major target of immunity is EBV glycoprotein 350/220 (gp350) that mediates attachment to B cells through complement receptor 2 (CR2/CD21).
Background & Aims: Integrin αvβ6 is highly expressed on certain activated epithelia, where it mediates attachment to fibronectin and serves as coreceptor for the activation of latent transforming growth factor (TGF -β1.
C32 cells have been shown to express the integrin alpha v beta 3 (Vn receptor) which mediates attachment to Vn and Fb in a GRGDS-sensitive manner.
Cadherins are components of the adherens junction (AJ), and they span the cell membrane to mediate attachment to adjacent cells.
The Haemophilus influenzae HMW1 protein is a high-molecular weight non-pilus adhesin that mediates attachment to human epithelial cells, an essential step in the pathogenesis of H. influenzae disease [1] [3].
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